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美國MP-原裝現(xiàn)貨-DSS-硫酸葡聚糖
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訂貨量(瓶)
¥16000.00
≥1
¥15000.00
≥5
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DSS-超有效的腸炎造模試劑
葡聚糖硫酸鈉(DSS)是葡聚糖的聚陰離子衍生物。我們的DSS因為其具有超高質(zhì)量,純度和可重復(fù)性,使其應(yīng)用于很多領(lǐng)域,包括:臨床,分子生物學(xué),生物醫(yī)學(xué)甚至化妝品領(lǐng)域.
葡聚糖硫酸鈉具有如下特性:
炎性腸?。↖BD)的特征是慢性、復(fù)發(fā)性胃腸道炎癥,其可增加患結(jié)腸炎相關(guān)性癌癥的風(fēng)險。已經(jīng)有幾種動物模型被用于研究腸炎,其中一個模型就是通過小鼠口服葡聚糖硫酸鈉(DSS)的水溶液來誘導(dǎo)慢性腸炎。DSS誘導(dǎo)的腸炎模型是自發(fā)的,并且可以用來評估IBD的治療潛力.
使用超有效的葡聚糖硫酸鈉可以加速您的IBD研究。我們的DSS具有以下優(yōu)勢:
超好的結(jié)果!
Bamba等人(2012)對3種不同的DSS進行了比較分析,研究了它們的化學(xué)性質(zhì)和細胞毒性以及引發(fā)的腸炎嚴重性。他們的研究結(jié)論是,我們的DSS可引發(fā)一種嚴重的腸炎,通過體重變化,DAI評分,結(jié)腸重量/長度和組織學(xué)評分這些指標顯示.
1) Mouli, V.P., Ananthakrishnan, A.N. Review article: Vitamin D and inflammatory bowel diseases (2014) Alimentary Pharmacology and Therapeutics, 39 (2), pp. 125-136. 2) Salcedo, R., Cataisson, C., Hasan, U., Yuspa, S.H., Trinchieri, G. MyD88 and its divergent toll in carcinogenesis (2013) Trends in Immunology, 34 (8), pp. 379-389. 3) Zindl, C.L., Lai, J.-F., Lee, Y.K., Maynard, C.L., Harbour, S.N., Ouyang, W., Chaplin, D.D., Weaver, C.T. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis (2013) Proceedings of the National Academy of Sciences of the United States of America, 110 (31), pp. 12768-12773. 4) Tanaka, T., Ishikawa, H. Mast cells and inflammation-associated colorectal carcinogenesis (2013) Seminars in Immunopathology, 35 (2), pp. 245-254. 5) Tanaka, T. Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention (2012) International Journal of Inflammation, 2012, art. no. 658786. 5) Sussman, D.A., Santaolalla, R., Strobel, S., Dheer, R., Abreu, M.T. Cancer in inflammatory bowel disease: Lessons from animal models (2012) Current Opinion in Gastroenterology, 28 (4), pp. 327-333. 6) Per??e, M., Cerar, A. Dextran sodium sulphate colitis mouse model: Traps and tricks (2012) Journal of Biomedicine and Biotechnology, 2012, art. no. 718617. 7) Vora, P., McGovern, D.P.B. LRRK2 as a negative regulator of NFAT: Implications for the pathogenesis of inflammatory bowel disease (2012) Expert Review of Clinical Immunology, 8 (3), pp. 227-229. 8) Zhao, W.-C., Song, L.-J., Deng, H.-Z. Protective effect of total alkaloids of sophora alopecuroides on dextran sulfate sodium-induced chronic colitis (2011) Chinese Journal of Integrative Medicine, 17 (8), pp. 616-624. 9) Azuma, Y.-T., Nakajima, H., Takeuchi, T. IL-19 as a potential therapeutic in autoimmune and inflammatory diseases (2011) Current Pharmaceutical Design, 17 (34), pp. 3776-3780. 10) Naito, Y., Takagi, T., Uchiyama, K., Yoshikawa, T. Heme oxygenase-1: A novel therapeutic target for gastrointestinal diseases (2011) Journal of Clinical Biochemistry and Nutrition, 48 (2), pp. 126-133. 11) Egea, L., Hirata, Y., Kagnoff, M.F. GM-CSF: A role in immune and inflammatory reactions in the intestine (2010) Expert Review of Gastroenterology and Hepatology, 4 (6), pp. 723-731. 12) Takagi, T., Naito, Y., Uchiyama, K., Yoshikawa, T. The role of heme oxygenase and carbon monoxide in inflammatory bowel disease (2010) Redox Report, 15 (5), pp. 193-201. 13) Shukla, P., Gupta, G., Singodia, D., Shukla, R., Verma, A.K., Dwivedi, P., Kansal, S., Mishra, P.R. Emerging trend in nano-engineered polyelectrolyte-based surrogate carriers for delivery of bioactives (2010) Expert Opinion on Drug Delivery, 7 (9), pp. 993-1011. 14) Solomon, L., Mansor, S., Mallon, P., Donnelly, E., Hoper, M., Loughrey, M., Kirk, S., Gardiner, K. The dextran sulphate sodium (DSS) model of colitis: An overview (2010) Comparative Clinical Pathology, 19 (3), pp. 235-239. 15) Strauch, U.G., Grunwald, N., Obermeier, F., G??rster, S., Rath, H.C. Loss of CD103+ intestinal dendritic cells during colonic inflammation (2010) World Journal of Gastroenterology, 16 (1), pp. 21-29. 16) Maxwell, J.R., Brown, W.A., Smith, C.L., Byrne, F.R., Viney, J.L. Methods of inducing inflammatory bowel disease in mice (2009) Current Protocols in Pharmacology, (SUPPL.47), pp. 5.58.1-5.58.37. 17) Waldner, M.J., Neurath, M.F. Chemically induced mouse models of colitis (2009) Current Protocols in Pharmacology, (SUPPL. 46), pp. 5.55.1-5.55.15. 18) Nishihira, J., Mitsuyama, K. Overview of the role of macrophage migration inhibitory factor (MIF) in inflammatory bowel disease (2009) Current Pharmaceutical Design, 15 (18), pp. 2104-2109. 19) Soeda, S., Sakata, A., Ochiai, T., Yasuda, K., Kuramoto, Y., Shimeno, H., Toda, A., Eyanagi, R., Hikishima, S., Yokomastu, T., Shibuya, S. Sphingomyelinase inhibition suggests a possible new strategy for the treatment of inflammatory bowel disease (2008) Current Drug Therapy, 3 (3), pp. 218-225. 20) Kawada, M., Arihiro, A., Mizoguchi, E. Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease (2007) World Journal of Gastroenterology, 13 (42), pp. 5581-5593. 21) Clapper, M.L., Cooper, H.S., Chang, W.-C.L. Dextran sulfate sodium-induced colitis-associated neoplasia: A promising model for the development of chemopreventive interventions (2007) Acta Pharmacologica Sinica, 28 (9), pp. 1450-1459. 22) Butterworth, J.R. Another important function for an old friend! The role of iron in colorectal carcinogenesis (2006) Gut, 55 (10), pp. 1384-1386. 23) Di Pace, R.F., Massa, S., Ribeiro, O.G., Cabrera, W.H.K., De Franco, M., Starobinas, N., Seman, M., Iba?±ez, O.C.M. Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness (2006) Carcinogenesis, 27 (8), pp. 1517-1525. 24) Guarner, F. Inulin and oligofructose: Impact on intestinal diseases and disorders (2005) British Journal of Nutrition, 93 (SUPP), pp. S61-S65. 25) Dagenais, S., Haldeman, S., Wooley, J.R. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: A critical review of the literature (2005) Spine Journal, 5 (3), pp. 310-328. Cited 30 times. 26) Mirvish, S.S., Haorah, J., Zhou, L., Hartman, M., Morris, C.R., Clapper, M.L. N-Nitroso compounds in the gastrointestinal tract of rats and in the feces of mice with induced colitis or fed hot dogs or beef (2003) Carcinogenesis, 24 (3), pp. 595-603. |
溫馨提示:不可用于臨床治療。 |